Research has shown that long-term drug use results in significant changes in brain function that persist long after the individual stops using drugs. These drug-induced changes in brain function may have many behavioral consequences, including the compulsion to use drugs despite adverse consequences - the defining characteristic of addiction. Research studies indicate that even the most severely addicted individuals can participate actively in treatment and that active participation is essential to good outcomes.
Source: The National Institute on Drug Abuse (NIDA) website (http://www.nida.nih.gov/)
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